Analysis of synergism between stem cell factor and granulocyte-macrophage colony-stimulating factor on human megakaryoblastic cells: an increase in tyrosine …
T Kamijo, K Koike, K Takeuch, T Higuchi, N Sawai… - Leukemia research, 1997 - Elsevier
In normal hematopoiesis, stem cell factor (SCF) stimulates survival, proliferation and
differentiation of hematopoietic progenitors. Although SCF acts synergistically with a variety
of cytokines, the mechanism of growth factor-cooperation remains to be determined. To
analyze the synergism between SCF and granulocyte-macrophage colony-stimulating factor
(GM-CSF), we established a new megakaryoblastic cell line, HML-2, by culture in the
presence of both SCF and GM-CSF. While SCF alone or GM-CSF alone supported modest …
differentiation of hematopoietic progenitors. Although SCF acts synergistically with a variety
of cytokines, the mechanism of growth factor-cooperation remains to be determined. To
analyze the synergism between SCF and granulocyte-macrophage colony-stimulating factor
(GM-CSF), we established a new megakaryoblastic cell line, HML-2, by culture in the
presence of both SCF and GM-CSF. While SCF alone or GM-CSF alone supported modest …
