Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein
TC Theoharides, W Sieghart, P Greengard… - Science, 1980 - science.org
TC Theoharides, W Sieghart, P Greengard, WW Douglas
Science, 1980•science.orgCromolyn inhibited histamine release from mast cells that was induced by a classic
secretagogue and correspondingly increased incorporation of radioactive phosphate into a
78,000-dalton protein. These effects on histamine secretion and on protein phosphorylation
were rapid in onset and both showed tachyphylaxis. Cromolyn may therefore act by altering
the phosphorylation of a protein involved in the regulation of secretion.
secretagogue and correspondingly increased incorporation of radioactive phosphate into a
78,000-dalton protein. These effects on histamine secretion and on protein phosphorylation
were rapid in onset and both showed tachyphylaxis. Cromolyn may therefore act by altering
the phosphorylation of a protein involved in the regulation of secretion.
Cromolyn inhibited histamine release from mast cells that was induced by a classic secretagogue and correspondingly increased incorporation of radioactive phosphate into a 78,000-dalton protein. These effects on histamine secretion and on protein phosphorylation were rapid in onset and both showed tachyphylaxis. Cromolyn may therefore act by altering the phosphorylation of a protein involved in the regulation of secretion.
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