Recent advances in the study of the biosynthesis and functions of sulfated glycosaminoglycans
K Sugahara, H Kitagawa - Current opinion in structural biology, 2000 - Elsevier
K Sugahara, H Kitagawa
Current opinion in structural biology, 2000•ElsevierRecent cDNA cloning of the glycosyltransferases involved in the synthesis of the sulfated
glycosaminoglycan sidechains of proteoglycans has provided important clues to answering
long-standing questions concerning the mechanisms of both chain polymerization and the
biosynthetic sorting of glucosaminoglycans (heparin/heparan sulfate) and
galactosaminoglycans (chondroitin/dermatan sulfate). These biosynthetic mechanisms are
crucial to the expression and regulation of the biological functions of glycosaminoglycans in …
glycosaminoglycan sidechains of proteoglycans has provided important clues to answering
long-standing questions concerning the mechanisms of both chain polymerization and the
biosynthetic sorting of glucosaminoglycans (heparin/heparan sulfate) and
galactosaminoglycans (chondroitin/dermatan sulfate). These biosynthetic mechanisms are
crucial to the expression and regulation of the biological functions of glycosaminoglycans in …
Recent cDNA cloning of the glycosyltransferases involved in the synthesis of the sulfated glycosaminoglycan sidechains of proteoglycans has provided important clues to answering long-standing questions concerning the mechanisms of both chain polymerization and the biosynthetic sorting of glucosaminoglycans (heparin/heparan sulfate) and galactosaminoglycans (chondroitin/dermatan sulfate). These biosynthetic mechanisms are crucial to the expression and regulation of the biological functions of glycosaminoglycans in development and pathophysiology.
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