[HTML][HTML] Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase½ activation in postcapillary endothelium
A Parenti, L Morbidelli, XL Cui, JG Douglas… - Journal of Biological …, 1998 - ASBMB
We recently demonstrated that nitric oxide (NO) significantly contributes to the mitogenic
effect of vascular endothelial growth factor (VEGF), suggesting a role for the NO pathway in
the signaling cascade following kinase-derivative receptor activation in vascular
endothelium. The aim of this study was to investigate the intracellular pathways linked to
VEGF/NO-induced endothelial cell proliferation. We assessed the activity of the mitogen-
activated protein kinase (MAPK) that is specifically activated by growth factors, extracellular …
effect of vascular endothelial growth factor (VEGF), suggesting a role for the NO pathway in
the signaling cascade following kinase-derivative receptor activation in vascular
endothelium. The aim of this study was to investigate the intracellular pathways linked to
VEGF/NO-induced endothelial cell proliferation. We assessed the activity of the mitogen-
activated protein kinase (MAPK) that is specifically activated by growth factors, extracellular …