[HTML][HTML] Genetic deficiency of acylation stimulating protein (ASP (C3ades-Arg)) does not cause hyperapobetalipoproteinemia in mice
RA Wetsel, J Kildsgaard, E Zsigmond, W Liao… - Journal of Biological …, 1999 - ASBMB
The acylation stimulating protein (ASP) is a 76-amino acid peptide that has been proposed
as a potent mediator of triglyceride synthesis and, when functionally impaired, as a major
cause of hyperapobetalipoproteinemia (HyperapoB). Purification and sequence analysis of
ASP from human sera have revealed that ASP is identical to the complement C3-derived
activation peptide C3ades-Arg. Because C3 is the precursor for C3ades-Arg and therefore
ASP, a deficiency in C3 would be predicted to result in a phenotype characteristic of …
as a potent mediator of triglyceride synthesis and, when functionally impaired, as a major
cause of hyperapobetalipoproteinemia (HyperapoB). Purification and sequence analysis of
ASP from human sera have revealed that ASP is identical to the complement C3-derived
activation peptide C3ades-Arg. Because C3 is the precursor for C3ades-Arg and therefore
ASP, a deficiency in C3 would be predicted to result in a phenotype characteristic of …