[HTML][HTML] Molecular basis of insulin-stimulated GLUT4 vesicle trafficking: location! location! location!
JE Pessin, DC Thurmond, JS Elmendorf… - Journal of Biological …, 1999 - ASBMB
Among all the diverse actions of insulin, one of the most critical and intensively studied is its
regulation of glucose homeostasis. In the postabsorptive state, insulin action in muscle and
adipose tissue results in increased glucose uptake from the circulation, thereby maintaining
plasma euglycemia and preventing hyperglycemia (1–3). Defects in this pathway result in
insulin resistance, a condition in which excessive concentrations of insulin are required to
reduce blood glucose levels and often precede the development of frank Type II diabetes (3 …
regulation of glucose homeostasis. In the postabsorptive state, insulin action in muscle and
adipose tissue results in increased glucose uptake from the circulation, thereby maintaining
plasma euglycemia and preventing hyperglycemia (1–3). Defects in this pathway result in
insulin resistance, a condition in which excessive concentrations of insulin are required to
reduce blood glucose levels and often precede the development of frank Type II diabetes (3 …