[HTML][HTML] Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and α catenin
M Itoh, K Morita, S Tsukita - Journal of Biological Chemistry, 1999 - ASBMB
ZO-2, a member of the MAGUK family, was thought to be specific for tight junctions (TJs) in
contrast to ZO-1, another MAGUK family member, which is localized at TJs and adherens
junctions (AJs) in epithelial and nonepithelial cells, respectively. Mouse ZO-2 cDNA was
isolated, and a specific polyclonal antibody was generated using corresponding synthetic
peptides as antigens. Immunofluorescence microscopy with this polyclonal antibody
revealed that, similarly to ZO-1, in addition to TJs in epithelial cells, ZO-2 was also …
contrast to ZO-1, another MAGUK family member, which is localized at TJs and adherens
junctions (AJs) in epithelial and nonepithelial cells, respectively. Mouse ZO-2 cDNA was
isolated, and a specific polyclonal antibody was generated using corresponding synthetic
peptides as antigens. Immunofluorescence microscopy with this polyclonal antibody
revealed that, similarly to ZO-1, in addition to TJs in epithelial cells, ZO-2 was also …