Proteolytic cleavage of CD25, the α subunit of the human T cell interleukin 2 receptor, by Der p 1, a major mite allergen with cysteine protease activity
O Schulz, HF Sewell, F Shakib - The Journal of experimental medicine, 1998 - rupress.org
O Schulz, HF Sewell, F Shakib
The Journal of experimental medicine, 1998•rupress.orgRecent reports have indicated that the cysteine protease activity of Der p 1 may play a
significant role in its ability to elicit IgE antibody responses, mainly through cleavage of
membrane CD23 on B cells and interleukin (IL)-4 synthesis and secretion from mast cells
and basophils. Here we demonstrate for the first time that Der p 1 also cleaves the α subunit
of the IL-2 receptor (IL-2R or CD25) from the surface of human peripheral blood T cells and,
as a result, these cells show markedly diminished proliferation and interferon γ secretion in …
significant role in its ability to elicit IgE antibody responses, mainly through cleavage of
membrane CD23 on B cells and interleukin (IL)-4 synthesis and secretion from mast cells
and basophils. Here we demonstrate for the first time that Der p 1 also cleaves the α subunit
of the IL-2 receptor (IL-2R or CD25) from the surface of human peripheral blood T cells and,
as a result, these cells show markedly diminished proliferation and interferon γ secretion in …
Recent reports have indicated that the cysteine protease activity of Der p 1 may play a significant role in its ability to elicit IgE antibody responses, mainly through cleavage of membrane CD23 on B cells and interleukin (IL)-4 synthesis and secretion from mast cells and basophils. Here we demonstrate for the first time that Der p 1 also cleaves the α subunit of the IL-2 receptor (IL-2R or CD25) from the surface of human peripheral blood T cells and, as a result, these cells show markedly diminished proliferation and interferon γ secretion in response to potent stimulation by anti-CD3 antibody. Given that the IL-2R is pivotal for the propagation of Th1 cells, its cleavage by Der p 1 may consequently bias the immune response towards Th2 cells, thereby creating an allergic microenvironment.
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