[HTML][HTML] Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells
Activation of stress-activated protein kinases, including the p38 and the c-Jun NH 2-terminal
kinases (JNK), have been associated with the onset of cardiac hypertrophy and cell death in
response to hemodynamic overload and ischemia/reperfusion injury. Upon infection of
cultured neonatal rat cardiac myocytes with recombinant adenoviral vectors expressing a
wild type and a constitutively active mutant of MKK7 (or JNKK2), JNK was specifically
activated without affecting other mitogen-activated protein kinases, including extracellular …
kinases (JNK), have been associated with the onset of cardiac hypertrophy and cell death in
response to hemodynamic overload and ischemia/reperfusion injury. Upon infection of
cultured neonatal rat cardiac myocytes with recombinant adenoviral vectors expressing a
wild type and a constitutively active mutant of MKK7 (or JNKK2), JNK was specifically
activated without affecting other mitogen-activated protein kinases, including extracellular …