Aberrant activation of the androgen receptor through signaling pathways independent of
androgen may be responsible for the progression of prostate tumors to the rapidly
proliferating androgen-independent state. In this study, the effects of protein kinase A
modulators on human androgen receptor activity were tested. Using an adenoviral DNA
delivery system, we demonstrate that the androgen receptor can be activated by a protein
kinase A activator, forskolin, in the absence of androgen when androgen receptor is co …