Extracellular correction of the androgen-receptor transformation defect in two families with complete androgen resistance
B Gottlieb, M Kaufman, L Pinsky, G Leboeuf… - Journal of Steroid …, 1987 - Elsevier
We have characterized the cellular and extracellur phenotype of the mutant androgen
receptor (AR) from two families who have complete androgen resistance despite a normal
androgen-binding capacity (B m) in their genital skin fibroblasts (GSF). The cellular
receptors fail to up-regulate their basal AR activity in response to prolonged incubation with
5α-dihydrotestosterone (DHT), or with two synthetic androgens, methyltrienolone (MT) and
mibolerone (MB), and form AR complexes with increased equilibrium (K d) and non …
receptor (AR) from two families who have complete androgen resistance despite a normal
androgen-binding capacity (B m) in their genital skin fibroblasts (GSF). The cellular
receptors fail to up-regulate their basal AR activity in response to prolonged incubation with
5α-dihydrotestosterone (DHT), or with two synthetic androgens, methyltrienolone (MT) and
mibolerone (MB), and form AR complexes with increased equilibrium (K d) and non …
