[HTML][HTML] Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARα and PPARγ activators

G Martin, K Schoonjans, AM Lefebvre, B Staels… - Journal of Biological …, 1997 - ASBMB
Intracellular fatty acid (FA) concentrations are in part determined by a regulated
import/export system that is controlled by two key proteins, ie fatty acid transport protein
(FATP) and acyl-CoA synthetase (ACS), which respectively facilitate the transport of FAs
across the cell membrane and their esterification to prevent their efflux. The aim of this
investigation was to analyze the expression pattern of FATP and ACS and to determine
whether their expression was altered by agents that affect FA metabolism through the …