Role of cytokines in rheumatoid arthritis
M Feldmann, FM Brennan… - Annual review of …, 1996 - annualreviews.org
▪ Abstract Analysis of cytokine mRNA and protein in rheumatoid arthritis tissue revealed that
many proinflammatory cytokines such as TNFα, IL-1, IL-6, GM-CSF, and chemokines such
as IL-8 are abundant in all patients regardless of therapy. This is compensated to some
degree by the increased production of anti-inflammatory cytokines such as IL-10 and TGFβ
and cytokine inhibitors such as IL-1ra and soluble TNF-R. However, this upregulation in
homeostatic regulatory mechanisms is not sufficient as these are unable to neutralize all the …
many proinflammatory cytokines such as TNFα, IL-1, IL-6, GM-CSF, and chemokines such
as IL-8 are abundant in all patients regardless of therapy. This is compensated to some
degree by the increased production of anti-inflammatory cytokines such as IL-10 and TGFβ
and cytokine inhibitors such as IL-1ra and soluble TNF-R. However, this upregulation in
homeostatic regulatory mechanisms is not sufficient as these are unable to neutralize all the …
Development of anti-TNF therapy for rheumatoid arthritis
M Feldmann - Nature Reviews Immunology, 2002 - nature.com
The aetiology of systemic, autoimmune, chronic inflammatory diseases—such as
rheumatoid arthritis—is not known, and their pathogenesis is complex and multifactorial.
However, progress in the characterization of intercellular mediators—proteins that are now
known as cytokines—has led to the realization that one cytokine, tumour-necrosis factor
(TNF; previously known as TNF-α), has an important role in the pathogenesis of rheumatoid
arthritis. This discovery heralded a new era of targeted and highly effective therapeutics for …
rheumatoid arthritis—is not known, and their pathogenesis is complex and multifactorial.
However, progress in the characterization of intercellular mediators—proteins that are now
known as cytokines—has led to the realization that one cytokine, tumour-necrosis factor
(TNF; previously known as TNF-α), has an important role in the pathogenesis of rheumatoid
arthritis. This discovery heralded a new era of targeted and highly effective therapeutics for …