TY - JOUR AU - Herman, Mark A. AU - Campbell, Jonathan E. AU - D’Alessio, David A. T1 - One small step for mice, one giant leap for GWAS? PY - 2019/10/01/ AB - Genome-wide association studies (GWAS) have provided a wealth of information on potential disease-associated genes in the human population. In particular, several loci have been associated with type 2 diabetes (T2D). However, due to the complexity of the disease, it has been a challenge to unravel the exact effects of specific loci on T2D pathogenesis. In this issue of the JCI, Keller and colleagues developed a systems genetic approach to identify insulin secretion–associated genes in nondiabetic mice followed by tissue-level and functional phenotyping. Several of the loci identified were syntenic with human T2D-related loci, indicating that this approach may be feasible for discerning genetic variation in nondiabetic individuals that may lead to the development of T2D. JF - The Journal of Clinical Investigation JA - J Clin Invest SN - 0021-9738 DO - 10.1172/JCI131650 VL - 129 IS - 10 UR - https://doi.org/10.1172/JCI131650 SP - 4083 EP - 4085 PB - The American Society for Clinical Investigation ER -