Nuclear but not mitochondrial-encoded oxidative phosphorylation genes are altered in aging, mild cognitive impairment, and Alzheimer's disease
D Mastroeni, OM Khdour, E Delvaux, J Nolz… - Alzheimer's & …, 2017 - Elsevier
Introduction We have comprehensively described the expression profiles of mitochondrial
DNA and nuclear DNA genes that encode subunits of the respiratory oxidative
phosphorylation (OXPHOS) complexes (I–V) in the hippocampus from young controls, age
matched, mild cognitively impaired (MCI), and Alzheimer's disease (AD) subjects. Methods
Hippocampal tissues from 44 non-AD controls (NC), 10 amnestic MCI, and 18 AD cases
were analyzed on Affymetrix Hg-U133 plus 2.0 arrays. Results The microarray data revealed …
DNA and nuclear DNA genes that encode subunits of the respiratory oxidative
phosphorylation (OXPHOS) complexes (I–V) in the hippocampus from young controls, age
matched, mild cognitively impaired (MCI), and Alzheimer's disease (AD) subjects. Methods
Hippocampal tissues from 44 non-AD controls (NC), 10 amnestic MCI, and 18 AD cases
were analyzed on Affymetrix Hg-U133 plus 2.0 arrays. Results The microarray data revealed …
