B lymphocytes directly contribute to tissue fibrosis in patients with IgG4-related disease
E Della-Torre, E Rigamonti, C Perugino… - Journal of Allergy and …, 2020 - Elsevier
Background IgG 4-related disease (IgG 4-RD) is a fibroinflammatory condition marked by
rapid clinical improvement after selective depletion of B lymphocytes with rituximab. This
feature suggests that B cells might participate in fibrogenesis and wound healing. Objective
In the present work we aimed to demonstrate that B lymphocytes contribute directly to tissue
fibrosis in patients with IgG 4-RD. Methods Total circulating CD19+ B lymphocytes, naive B
cells, memory B cells, or plasmablasts from patients with IgG 4-RD were cultivated with …
rapid clinical improvement after selective depletion of B lymphocytes with rituximab. This
feature suggests that B cells might participate in fibrogenesis and wound healing. Objective
In the present work we aimed to demonstrate that B lymphocytes contribute directly to tissue
fibrosis in patients with IgG 4-RD. Methods Total circulating CD19+ B lymphocytes, naive B
cells, memory B cells, or plasmablasts from patients with IgG 4-RD were cultivated with …