Tissue factor de-encryption: ionophore treatment induces changes in tissue factor activity by phosphatidylserine-dependent and-independent mechanisms
AS Wolberg, DM Monroe, HR Roberts… - Blood coagulation & …, 1999 - journals.lww.com
Coagulation is initiated on tissue-factor-bearing cells when factor Vila complexes with
membrane-bound tissue factor and activates factors X and IX. Cellular tissue factor activity
does not correlate with tissue factor antigen; treatment with calcium ionophore rapidly
increases tissue factor activity without increasing tissue factor antigen. Our study examined
the effect of calcium ionophore A23187 on tissue factor activity of freshly isolated,
lipopolysaccharide-stimulated monocytes and non-transformed human dermal fibroblasts …
membrane-bound tissue factor and activates factors X and IX. Cellular tissue factor activity
does not correlate with tissue factor antigen; treatment with calcium ionophore rapidly
increases tissue factor activity without increasing tissue factor antigen. Our study examined
the effect of calcium ionophore A23187 on tissue factor activity of freshly isolated,
lipopolysaccharide-stimulated monocytes and non-transformed human dermal fibroblasts …