Direct action of endothelin-1 on podocytes promotes diabetic glomerulosclerosis
O Lenoir, M Milon, A Virsolvy, C Hénique… - Journal of the …, 2014 - journals.lww.com
The endothelin system has emerged as a novel target for the treatment of diabetic
nephropathy. Endothelin-1 promotes mesangial cell proliferation and sclerosis. However, no
direct pathogenic effect of endothelin-1 on podocytes has been shown in vivo and
endothelin-1 signaling in podocytes has not been investigated. This study investigated
endothelin effects in podocytes during experimental diabetic nephropathy. Stimulation of
primary mouse podocytes with endothelin-1 elicited rapid calcium transients mediated by …
nephropathy. Endothelin-1 promotes mesangial cell proliferation and sclerosis. However, no
direct pathogenic effect of endothelin-1 on podocytes has been shown in vivo and
endothelin-1 signaling in podocytes has not been investigated. This study investigated
endothelin effects in podocytes during experimental diabetic nephropathy. Stimulation of
primary mouse podocytes with endothelin-1 elicited rapid calcium transients mediated by …