Pathogenic mechanisms of lipid mediator lysophosphatidic acid in chronic pain
H Ueda - Progress in lipid research, 2021 - Elsevier
A number of membrane lipid-derived mediators play pivotal roles in the initiation,
maintenance, and regulation of various types of acute and chronic pain. Acute pain,
comprising nociceptive and inflammatory pain warns us about the presence of damage or
harmful stimuli. However, it can be efficiently reversed by opioid analgesics and anti-
inflammatory drugs. Prostaglandin E 2 and I 2, the representative lipid mediators, are well-
known causes of acute pain. However, some lipid mediators such as lipoxins, resolvins or …
maintenance, and regulation of various types of acute and chronic pain. Acute pain,
comprising nociceptive and inflammatory pain warns us about the presence of damage or
harmful stimuli. However, it can be efficiently reversed by opioid analgesics and anti-
inflammatory drugs. Prostaglandin E 2 and I 2, the representative lipid mediators, are well-
known causes of acute pain. However, some lipid mediators such as lipoxins, resolvins or …