TRPV1 agonism inhibits endothelial cell inflammation via activation of eNOS/NO pathway
Y Wang, L Cui, H Xu, S Liu, F Zhu, F Yan, S Shen… - Atherosclerosis, 2017 - Elsevier
Background and aims Transient receptor potential vanilloid type 1 channel (TRPV1) is found
to be expressed in endothelial cells (ECs) and activate endothelial nitric oxide synthase
(eNOS). Recent studies implicate TRPV1 in attenuating inflammatory responses. However,
the mechanisms underlying the beneficial effects remain unclear. In this study, we
investigated whether TRPV1 suppresses inflammatory responses of ECs via eNOS/NO
pathway. Methods Human umbilical vein endothelial cells (HUVECs) and renal …
to be expressed in endothelial cells (ECs) and activate endothelial nitric oxide synthase
(eNOS). Recent studies implicate TRPV1 in attenuating inflammatory responses. However,
the mechanisms underlying the beneficial effects remain unclear. In this study, we
investigated whether TRPV1 suppresses inflammatory responses of ECs via eNOS/NO
pathway. Methods Human umbilical vein endothelial cells (HUVECs) and renal …