[HTML][HTML] Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A
D Wang, J Prakash, P Nguyen… - Journal of Biological …, 2012 - ASBMB
Pulmonary artery hypertension (PAH) patients exhibit elevated levels of inflammatory
cytokines and infiltration of inflammatory cells in the lung. Concurrently, mutations of bmpr2,
the gene encoding the type II receptor of bone morphogenetic proteins (BMP), are found
in∼ 75% of patients with familial PAH, but a possible nexus between increased
inflammation and diminished BMP signaling has hitherto remained elusive. We previously
showed that BMP4 triggers nuclear localization of the Myocardin-related transcription factor …
cytokines and infiltration of inflammatory cells in the lung. Concurrently, mutations of bmpr2,
the gene encoding the type II receptor of bone morphogenetic proteins (BMP), are found
in∼ 75% of patients with familial PAH, but a possible nexus between increased
inflammation and diminished BMP signaling has hitherto remained elusive. We previously
showed that BMP4 triggers nuclear localization of the Myocardin-related transcription factor …