[HTML][HTML] The nuclear factor-κB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter
WV Berghe, K De Bosscher, E Boone… - Journal of Biological …, 1999 - ASBMB
Expression of the pleiotropic cytokine interleukin (IL)-6 can be stimulated by the
proinflammatory cytokine tumor necrosis factor (TNF) and the microbial alkaloid
staurosporine (STS). In this report, the transcriptional mechanisms were thoroughly
investigated. Whereas transcription factors binding to the activator protein-1-, cAMP-
responsive element-, and CAAT enhancer-binding protein-responsive sequences are
necessary for gene activation by STS, nuclear factor (NF)-κB alone is responsible and …
proinflammatory cytokine tumor necrosis factor (TNF) and the microbial alkaloid
staurosporine (STS). In this report, the transcriptional mechanisms were thoroughly
investigated. Whereas transcription factors binding to the activator protein-1-, cAMP-
responsive element-, and CAAT enhancer-binding protein-responsive sequences are
necessary for gene activation by STS, nuclear factor (NF)-κB alone is responsible and …