[HTML][HTML] Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis
Glutathione peroxidase 4 (Gpx4) is uniquely involved in the detoxification of oxidative
damage to membrane lipids. Our previous studies showed that Gpx4 is essential for mouse
survival and that Gpx4 deficiency makes cells vulnerable to oxidative injury. In the present
study, we generated two lines of transgenic mice overexpressing Gpx4 (Tg (GPX4) mice)
using a genomic clone containing the human GPX4 gene. Both lines of Tg-(GPX4) mice, Tg5
and Tg6, had elevated levels of Gpx4 (mRNA and protein) in all tissues investigated, and …
damage to membrane lipids. Our previous studies showed that Gpx4 is essential for mouse
survival and that Gpx4 deficiency makes cells vulnerable to oxidative injury. In the present
study, we generated two lines of transgenic mice overexpressing Gpx4 (Tg (GPX4) mice)
using a genomic clone containing the human GPX4 gene. Both lines of Tg-(GPX4) mice, Tg5
and Tg6, had elevated levels of Gpx4 (mRNA and protein) in all tissues investigated, and …