ERK MAP kinase in G1 cell cycle progression and cancer
S Torii, T Yamamoto, Y Tsuchiya, E Nishida - Cancer science, 2006 - Wiley Online Library
S Torii, T Yamamoto, Y Tsuchiya, E Nishida
Cancer science, 2006•Wiley Online LibraryThe extracellular‐signal‐regulated kinase (ERK) mitogen‐activated protein (MAP) kinase
signaling pathway plays an important role in various cellular responses, including cell
proliferation, cell differentiation and cell survival. Recent studies have identified a number of
Ras/ERK signaling‐related proteins, such as scaffold proteins and inhibitors. These proteins
modulate ERK signaling and thereby could give variations in ERK signaling outputs that
regulate cell fate decisions. Here we focus on the role of ERK signaling in cell cycle …
signaling pathway plays an important role in various cellular responses, including cell
proliferation, cell differentiation and cell survival. Recent studies have identified a number of
Ras/ERK signaling‐related proteins, such as scaffold proteins and inhibitors. These proteins
modulate ERK signaling and thereby could give variations in ERK signaling outputs that
regulate cell fate decisions. Here we focus on the role of ERK signaling in cell cycle …
The extracellular‐signal‐regulated kinase (ERK) mitogen‐activated protein (MAP) kinase signaling pathway plays an important role in various cellular responses, including cell proliferation, cell differentiation and cell survival. Recent studies have identified a number of Ras/ERK signaling‐related proteins, such as scaffold proteins and inhibitors. These proteins modulate ERK signaling and thereby could give variations in ERK signaling outputs that regulate cell fate decisions. Here we focus on the role of ERK signaling in cell cycle progression from G0/G1 to S phase and cancer. (Cancer Sci 2006; 97: 697–702)
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