[HTML][HTML] DACH1 inhibits transforming growth factor-β signaling through binding Smad4
K Wu, Y Yang, C Wang, MA Davoli, M D'Amico… - Journal of Biological …, 2003 - ASBMB
The vertebrate homologues of Drosophila dachsund, DACH1 and DACH2, have been
implicated as important regulatory genes in development. DACH1 plays a role in retinal and
pituitary precursor cell proliferation and DACH2 plays a specific role in myogenesis. DACH
proteins contain a domain (DS domain) that is conserved with the proto-oncogenes Ski and
Sno. Since the Ski/Sno proto-oncogenes repress AP-1 and SMAD signaling, we
hypothesized that DACH1 might play a similar cellular function. Herein, DACH1 was found …
implicated as important regulatory genes in development. DACH1 plays a role in retinal and
pituitary precursor cell proliferation and DACH2 plays a specific role in myogenesis. DACH
proteins contain a domain (DS domain) that is conserved with the proto-oncogenes Ski and
Sno. Since the Ski/Sno proto-oncogenes repress AP-1 and SMAD signaling, we
hypothesized that DACH1 might play a similar cellular function. Herein, DACH1 was found …