[HTML][HTML] Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive …

A Purushothaman, DR Hurst, C Pisano… - Journal of Biological …, 2011 - ASBMB
Heparanase acts as a master regulator of the aggressive tumor phenotype in part by
enhancing expression of proteins known to drive tumor progression (eg VEGF, MMP-9,
hepatocyte growth factor (HGF), and RANKL). However, the mechanism whereby this
enzyme regulates gene expression remains unknown. We previously reported that elevation
of heparanase levels in myeloma cells causes a dramatic reduction in the amount of
syndecan-1 in the nucleus. Because syndecan-1 has heparan sulfate chains and because …