Characterization of a T cell line bearing natural killer receptors and capable of creating psoriasis in a SCID mouse model system
BJ Nickoloff, B Bonish, BB Huang, SA Porcelli - Journal of dermatological …, 2000 - Elsevier
T cells bearing natural killer receptors (NKRs) such as CD94 and CD161 are present in
psoriasis. These immunocytes express several receptors for both classical and non-classical
class I MHC molecules. Whether T cells bearing NKRs in psoriatic lesions represent
immunoregulatory versus pathogenic immunocytes or are just bystander cells is unclear. To
address this issue, a CD94+/CD161+ T cell line was established from a psoriatic patient
using IL-2/superantigens, and the interaction between NK-T cells and keratinocytes was …
psoriasis. These immunocytes express several receptors for both classical and non-classical
class I MHC molecules. Whether T cells bearing NKRs in psoriatic lesions represent
immunoregulatory versus pathogenic immunocytes or are just bystander cells is unclear. To
address this issue, a CD94+/CD161+ T cell line was established from a psoriatic patient
using IL-2/superantigens, and the interaction between NK-T cells and keratinocytes was …