[HTML][HTML] Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic …

Y Kawai, LK Garduno, M Theodore, J Yang… - Journal of Biological …, 2011 - ASBMB
Activation of Nrf2 by covalent modifications that release it from its inhibitor protein Keap1 has
been extensively documented. In contrast, covalent modifications that may regulate its action
after its release from Keap1 have received little attention. Here we show that CREB-binding
protein induced acetylation of Nrf2, increased binding of Nrf2 to its cognate response
element in a target gene promoter, and increased Nrf2-dependent transcription from target
gene promoters. Heterologous sirtuin 1 (SIRT1) decreased acetylation of Nrf2 as well as …