[HTML][HTML] Alternative mRNA splicing of corepressors generates variants that play opposing roles in adipocyte differentiation

ML Goodson, BJ Mengeling, BA Jonas… - Journal of Biological …, 2011 - ASBMB
The SMRT and NCoR corepressors partner with, and help mediate repression by, a wide
variety of nuclear receptors and non-receptor transcription factors. Both SMRT and NCoR
are expressed by alternative mRNA splicing, resulting in the production of a series of
interrelated corepressor variants that differ in their tissue distribution and in their biochemical
properties. We report here that different corepressor splice variants can exert opposing
transcriptional and biological effects during adipocyte differentiation. Most notably, the …