The Heymann nephritis antigenic complex: megalin (gp330) and RAP.

MG Farquhar, A Saito, D Kerjaschki… - Journal of the American …, 1995 - journals.lww.com
Heymann nephritis (HN) has been extensively studied as a model of human membranous
nephropathy since it was first described by Heymann in 1959. HN was induced in active
form by the immunization of rats with antigens derived from the proximal tubule brush
border, resulting in subepithelial glomerular immune deposits. HN was also induced
passively by the injection of antibrush border antibodies into normal rats. A breakthrough in
the understanding of the pathogenesis of HN was made in the 1970s, when it was …