[HTML][HTML] Clinical atovaquone-proguanil resistance of Plasmodium falciparum associated with cytochrome b codon 268 mutations
L Musset, O Bouchaud, S Matheron, L Massias… - Microbes and …, 2006 - Elsevier
Plasmodium falciparum resistance to atovaquone-proguanil has so far been associated with
Y268S or Y268N mutations in cytochrome b, although these changes were identified in only
seven of the 11 treatment failures. Here, we describe 10 new cases of atovaquone-proguanil
treatment failures among which the parasite resistance was confirmed in six cases, either by
identifying correct plasma drug concentrations or by observing in vitro atovaquone
resistance. Resistance was consistently associated with codon 268 mutations (Y268S or a …
Y268S or Y268N mutations in cytochrome b, although these changes were identified in only
seven of the 11 treatment failures. Here, we describe 10 new cases of atovaquone-proguanil
treatment failures among which the parasite resistance was confirmed in six cases, either by
identifying correct plasma drug concentrations or by observing in vitro atovaquone
resistance. Resistance was consistently associated with codon 268 mutations (Y268S or a …