[HTML][HTML] Metabolic fate of fumarate, a side product of the purine salvage pathway in the intraerythrocytic stages of Plasmodium falciparum
V Bulusu, V Jayaraman, H Balaram - Journal of biological chemistry, 2011 - ASBMB
In aerobic respiration, the tricarboxylic acid cycle is pivotal to the complete oxidation of
carbohydrates, proteins, and lipids to carbon dioxide and water. Plasmodium falciparum, the
causative agent of human malaria, lacks a conventional tricarboxylic acid cycle and
depends exclusively on glycolysis for ATP production. However, all of the constituent
enzymes of the tricarboxylic acid cycle are annotated in the genome of P. falciparum, which
implies that the pathway might have important, yet unidentified biosynthetic functions. Here …
carbohydrates, proteins, and lipids to carbon dioxide and water. Plasmodium falciparum, the
causative agent of human malaria, lacks a conventional tricarboxylic acid cycle and
depends exclusively on glycolysis for ATP production. However, all of the constituent
enzymes of the tricarboxylic acid cycle are annotated in the genome of P. falciparum, which
implies that the pathway might have important, yet unidentified biosynthetic functions. Here …