Quinoline resistance associated polymorphisms in the pfcrt, pfmdr1 and pfmrp genes of Plasmodium falciparum in Iran
J Ursing, S Zakeri, JP Gil, A Björkman - Acta tropica, 2006 - Elsevier
Plasmodium falciparum resistance to chloroquine (CQ) has been documented in Iran since
the early 1980s and has since gradually increased. Iran is therefore reviewing its national
drug policy for malaria control. We describe the prevalence of single nucleotide
polymorphisms (SNP) associated with quinoline drug resistance in south eastern Iran. Pre-
treatment blood from patients with uncomplicated but symptomatic P. falciparum infection
was analysed. Polymorphisms at codons 76, 152, 163 and 220 of the pfcrt gene …
the early 1980s and has since gradually increased. Iran is therefore reviewing its national
drug policy for malaria control. We describe the prevalence of single nucleotide
polymorphisms (SNP) associated with quinoline drug resistance in south eastern Iran. Pre-
treatment blood from patients with uncomplicated but symptomatic P. falciparum infection
was analysed. Polymorphisms at codons 76, 152, 163 and 220 of the pfcrt gene …