The cholinergic anti-inflammatory pathway: a critical review

D Martelli, MJ McKinley, RM McAllen - Autonomic Neuroscience, 2014 - Elsevier
From a critical review of the evidence on the cholinergic anti-inflammatory pathway and its
mode of action, the following conclusions were reached.(1) Both local and systemic
inflammation may be suppressed by electrical stimulation of the peripheral cut end of either
vagus.(2) The spleen mediates most of the systemic inflammatory response (measured by
TNF-α production) to systemic endotoxin and is also the site where that response is
suppressed by vagal stimulation.(3) The anti-inflammatory effect of vagal stimulation …