Evidence that elevated plasma corticosterone levels are the cause of reduced hypothalamic corticotrophin-releasing hormone gene expression in diabetes
MW Schwartz, AM Strack, MF Dallman - Regulatory peptides, 1997 - Elsevier
Uncontrolled diabetes mellitus causes both a sustained activation of the hypothalamic–
pituitary–adrenal (HPA) axis and reduced expression of corticotrophin-releasing hormone
(CRH) mRNA in the hypothalamic paraventricular nucleus (PVN). To investigate the role of
glucocorticoids in the regulation of CRH mRNA expression in the PVN of diabetic rats, we
studied surgically adrenalectomized (ADX) and sham-operated male Sprague-Dawley rats 4
days after iv injection of streptozotocin (STZ; 65 mg/kg iv) or vehicle. Among sham-operated …
pituitary–adrenal (HPA) axis and reduced expression of corticotrophin-releasing hormone
(CRH) mRNA in the hypothalamic paraventricular nucleus (PVN). To investigate the role of
glucocorticoids in the regulation of CRH mRNA expression in the PVN of diabetic rats, we
studied surgically adrenalectomized (ADX) and sham-operated male Sprague-Dawley rats 4
days after iv injection of streptozotocin (STZ; 65 mg/kg iv) or vehicle. Among sham-operated …