[HTML][HTML] Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide …
JM Lee, MJ Calkins, K Chan, YW Kan… - Journal of Biological …, 2003 - ASBMB
The antioxidant responsive element (ARE) mediates transcriptional regulation of phase II
detoxification enzymes and antioxidant proteins such as NAD (P) H: quinone
oxidoreductase (NQO1), glutathione S-transferases, and glutamate-cysteine ligase. In this
study, we demonstrate that NF-E2-related factor-2 (Nrf2) plays a major role in transcriptional
activation of ARE-driven genes and identify Nrf2-dependent genes by oligonucleotide
microarray analysis using primary cortical astrocytes from Nrf2+/+ and Nrf2−/− mice. Nrf2 …
detoxification enzymes and antioxidant proteins such as NAD (P) H: quinone
oxidoreductase (NQO1), glutathione S-transferases, and glutamate-cysteine ligase. In this
study, we demonstrate that NF-E2-related factor-2 (Nrf2) plays a major role in transcriptional
activation of ARE-driven genes and identify Nrf2-dependent genes by oligonucleotide
microarray analysis using primary cortical astrocytes from Nrf2+/+ and Nrf2−/− mice. Nrf2 …