The stromal and haematopoietic antigen-presenting cells that reside in secondary lymphoid organs
SJ Turley, AL Fletcher, KG Elpek - Nature Reviews Immunology, 2010 - nature.com
SJ Turley, AL Fletcher, KG Elpek
Nature Reviews Immunology, 2010•nature.comT cells encounter their cognate antigens in specialized compartments of secondary
lymphoid organs (SLOs). There, dendritic cells (DCs) present self and non-self antigens to T
cells, and promote immunity or tolerance depending on the availability of danger signals.
Resident stromal cells orchestrate the interaction between T cells and DCs by recruiting
them to T cell zones and guiding their migration within SLOs. Recent studies have shown
that SLO-resident stromal cells also have a crucial role in tolerance induction in the …
lymphoid organs (SLOs). There, dendritic cells (DCs) present self and non-self antigens to T
cells, and promote immunity or tolerance depending on the availability of danger signals.
Resident stromal cells orchestrate the interaction between T cells and DCs by recruiting
them to T cell zones and guiding their migration within SLOs. Recent studies have shown
that SLO-resident stromal cells also have a crucial role in tolerance induction in the …
Abstract
T cells encounter their cognate antigens in specialized compartments of secondary lymphoid organs (SLOs). There, dendritic cells (DCs) present self and non-self antigens to T cells, and promote immunity or tolerance depending on the availability of danger signals. Resident stromal cells orchestrate the interaction between T cells and DCs by recruiting them to T cell zones and guiding their migration within SLOs. Recent studies have shown that SLO-resident stromal cells also have a crucial role in tolerance induction in the periphery. In this Review, we discuss the roles of SLO-resident DCs and stromal cells in shaping T cell responses.
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