Recent data suggest that donor-specific memory T cells (T mem) are an independent risk
factor for rejection and poor graft function in patients and a major challenge for
immunosuppression minimizing strategies. Many tolerance induction protocols successfully
proven in small animal models eg costimulatory blockade, T cell depletion failed in patients.
Consequently, there is a need for more predictive transplant models to evaluate novel
promising strategies, such as adoptive transfer of regulatory T cells (Treg). We established a …