Signaling from the podocyte intercellular junction to the actin cytoskeleton
B George, LB Holzman - Seminars in nephrology, 2012 - Elsevier
Observations of hereditary glomerular disease support the contention that podocyte
intercellular junction proteins are essential for junction formation and maintenance. Genetic
deletion of most of these podocyte intercellular junction proteins results in foot process
effacement and proteinuria. This review focuses on the current understanding of molecular
mechanisms by which podocyte intercellular junction proteins such as the nephrin-neph1-
podocin–receptor complex coordinate cytoskeletal dynamics and thus intercellular junction …
intercellular junction proteins are essential for junction formation and maintenance. Genetic
deletion of most of these podocyte intercellular junction proteins results in foot process
effacement and proteinuria. This review focuses on the current understanding of molecular
mechanisms by which podocyte intercellular junction proteins such as the nephrin-neph1-
podocin–receptor complex coordinate cytoskeletal dynamics and thus intercellular junction …