[HTML][HTML] Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease
Recent demonstrations that the secretion, uptake, and interneuronal transfer of tau can be
modulated by disease-associated tau modifications suggest that secretion may be an
important element in tau-induced neurodegeneration. Here, we show that much of the tau
secreted by M1C cells occurs via exosomal release, a widely characterized mechanism that
mediates unconventional secretion of other aggregation-prone proteins (α-synuclein, prion
protein, and β-amyloid) in neurodegenerative disease. Exosome-associated tau is also …
modulated by disease-associated tau modifications suggest that secretion may be an
important element in tau-induced neurodegeneration. Here, we show that much of the tau
secreted by M1C cells occurs via exosomal release, a widely characterized mechanism that
mediates unconventional secretion of other aggregation-prone proteins (α-synuclein, prion
protein, and β-amyloid) in neurodegenerative disease. Exosome-associated tau is also …