The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition
XF Le, FX Claret, A Lammayot, L Tian… - Journal of Biological …, 2003 - ASBMB
Cyclin-dependent kinase (CDK) inhibitor p27 Kip1 binds to the cyclin E· CDK2 complex and
plays a major role in controlling cell cycle and cell growth. Our group and others have
reported that anti-HER2 monoclonal antibodies exert inhibitory effects on HER2-
overexpressing breast cancers through G 1 cell cycle arrest associated with induction of p27
Kip1 and reduction of CDK2. The role of p27 Kip1 in anti-HER2 antibody-induced cell cycle
arrest and growth inhibition is, however, still uncertain. Here we have provided several lines …
plays a major role in controlling cell cycle and cell growth. Our group and others have
reported that anti-HER2 monoclonal antibodies exert inhibitory effects on HER2-
overexpressing breast cancers through G 1 cell cycle arrest associated with induction of p27
Kip1 and reduction of CDK2. The role of p27 Kip1 in anti-HER2 antibody-induced cell cycle
arrest and growth inhibition is, however, still uncertain. Here we have provided several lines …
