Whither T-suppressors: if they didn't exist would we have to invent them?
M Cohn - Cellular immunology, 2004 - Elsevier
Arriving at an understanding of the role of suppressor T-cells (regulatory T-cells, CD4+
CD25+) depends on whether their functional repertoire is somatically selected to be anti-Self
or anti-Nonself. Immunologists are ambivalent; often publications espousing opposite views
share an author. Here the arguments are detailed that the suppressor repertoire is not
somatically selected to be anti-Self, but rather it is anti-Nonself. Therefore, suppression
cannot regulate the Self–Nonself discrimination; its function is to regulate the magnitude and …
CD25+) depends on whether their functional repertoire is somatically selected to be anti-Self
or anti-Nonself. Immunologists are ambivalent; often publications espousing opposite views
share an author. Here the arguments are detailed that the suppressor repertoire is not
somatically selected to be anti-Self, but rather it is anti-Nonself. Therefore, suppression
cannot regulate the Self–Nonself discrimination; its function is to regulate the magnitude and …