[HTML][HTML] The transcription factor CCAAT/enhancer-binding protein β regulates gluconeogenesis and phosphoenolpyruvate carboxykinase (GTP) gene transcription …
C Arizmendi, S Liu, C Croniger, V Poli… - Journal of biological …, 1999 - ASBMB
CCAAT/enhancer-binding protein (C/EBP) β and C/EBPα are members of the c/ebp gene
family and are highly expressed in mammalian liver and adipose tissue. C/EBPα is essential
for adipogenesis and neonatal gluconeogenesis, as shown by the C/EBPα knockout mouse.
C/EBPβ binds to several sequences of the phosphoenolpyruvate carboxykinase (PEPCK)
gene promoter with high affinity, and C/EBPβ protein is increased 200% in the livers of
streptozotocin-diabetic mice, concurrent with increased PEPCK mRNA. To elucidate the role …
family and are highly expressed in mammalian liver and adipose tissue. C/EBPα is essential
for adipogenesis and neonatal gluconeogenesis, as shown by the C/EBPα knockout mouse.
C/EBPβ binds to several sequences of the phosphoenolpyruvate carboxykinase (PEPCK)
gene promoter with high affinity, and C/EBPβ protein is increased 200% in the livers of
streptozotocin-diabetic mice, concurrent with increased PEPCK mRNA. To elucidate the role …