[HTML][HTML] Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) receptor-1 down-modulates VPF/VEGF receptor-2-mediated endothelial cell …
H Zeng, HF Dvorak, D Mukhopadhyay - Journal of Biological Chemistry, 2001 - ASBMB
Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) achieves its
multiple functions by activating two receptor tyrosine kinases, Flt-1 (VEGF receptor-1) and
KDR (VEGF receptor-2), both of which are selectively expressed on primary vascular
endothelium. To dissect the respective signaling pathways and biological functions
mediated by these receptors in primary endothelial cells with these two receptors intact, we
developed a chimeric receptor system in which the N terminus of the epidermal growth factor …
multiple functions by activating two receptor tyrosine kinases, Flt-1 (VEGF receptor-1) and
KDR (VEGF receptor-2), both of which are selectively expressed on primary vascular
endothelium. To dissect the respective signaling pathways and biological functions
mediated by these receptors in primary endothelial cells with these two receptors intact, we
developed a chimeric receptor system in which the N terminus of the epidermal growth factor …
