Protective effects of low and high doses of cyclosporin A against reoxygenation injury in isolated rat cardiomyocytes are associated with differential effects on …
EJ Griffiths, CJ Ocampo, JS Savage, MD Stern… - Cell calcium, 2000 - Elsevier
In this study we aimed to determine the concentration range of cyclosporin A (CsA) which
was effective in protecting against reoxygenation injury in isolated cardiomyocytes, and its
effects on intramitochondrial free calcium levels ([Ca2+] m). We also determined whether a
high [CsA] had any deleterious effect on normal myocyte function. Isolated adult rat
ventricular myocytes were placed in a chamber on the stage of a fluorescence microscope
for induction of hypoxia.[Ca2+] mwas determined from indo-1/am loaded cells where the …
was effective in protecting against reoxygenation injury in isolated cardiomyocytes, and its
effects on intramitochondrial free calcium levels ([Ca2+] m). We also determined whether a
high [CsA] had any deleterious effect on normal myocyte function. Isolated adult rat
ventricular myocytes were placed in a chamber on the stage of a fluorescence microscope
for induction of hypoxia.[Ca2+] mwas determined from indo-1/am loaded cells where the …
