Cytokines in inflammatory brain lesions: helpful and harmful
JE Merrill, EN Benveniste - Trends in neurosciences, 1996 - cell.com
JE Merrill, EN Benveniste
Trends in neurosciences, 1996•cell.comMultiple sclerosis (MS) is thought to be an autoimmune disease. In healthy individuals, the T
cells of the immune system, when activated by an infectious agent, regularly traffic across an
intact blood-brain barrier, survey the CNS and then leave. In MS, for reasons that are only
gradually being understood, certain events in the peripheral immune response and in the
brain cause some autoreactive T cells to stay in the CNS. Their presence initiates infiltration
by other leukocytes and activation and recruitment of endogenous glia to the inflammatory …
cells of the immune system, when activated by an infectious agent, regularly traffic across an
intact blood-brain barrier, survey the CNS and then leave. In MS, for reasons that are only
gradually being understood, certain events in the peripheral immune response and in the
brain cause some autoreactive T cells to stay in the CNS. Their presence initiates infiltration
by other leukocytes and activation and recruitment of endogenous glia to the inflammatory …
Abstract
Multiple sclerosis (MS) is thought to be an autoimmune disease. In healthy individuals, the T cells of the immune system, when activated by an infectious agent, regularly traffic across an intact blood-brain barrier, survey the CNS and then leave. In MS, for reasons that are only gradually being understood, certain events in the peripheral immune response and in the brain cause some autoreactive T cells to stay in the CNS. Their presence initiates infiltration by other leukocytes and activation and recruitment of endogenous glia to the inflammatory process, ultimately leading to the destruction of myelin and the myelin-producing cell, the oligodendrocyte, and the dysfunction of axons. The key mediators in the subsequent cycles of histological damage and repair, and clinical relapse and remission are thought to be adhesion molecules, chemokines and cytokines. Trends Neurosci. (1996) 19, 331–338
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