[HTML][HTML] The biology of P-selectin glycoprotein ligand-1: its role as a selectin counterreceptor in leukocyte-endothelial and leukocyte-platelet interaction
J Yang, BC Furie, B Furie - Thrombosis and haemostasis, 1999 - thieme-connect.com
J Yang, BC Furie, B Furie
Thrombosis and haemostasis, 1999•thieme-connect.comCell-cell interactions mediating leukocyte trafficking, thrombogene-sis and inflammation are
crucial for the host defense mechanism. The selectin family of integral membrane proteins
includes E-selectin, L-selectin and P-selectin. Selectins mediate tethering and rolling of
leukocytes to the vessel wall at the site of inflammation. The counter-receptor for P-selectin
and possibly the other selectins is P-selectin glycoprotein ligand-1 (PSGL-1). This review
focuses on the properties and biology of PSGL-1.
crucial for the host defense mechanism. The selectin family of integral membrane proteins
includes E-selectin, L-selectin and P-selectin. Selectins mediate tethering and rolling of
leukocytes to the vessel wall at the site of inflammation. The counter-receptor for P-selectin
and possibly the other selectins is P-selectin glycoprotein ligand-1 (PSGL-1). This review
focuses on the properties and biology of PSGL-1.
Cell-cell interactions mediating leukocyte trafficking, thrombogene-sis and inflammation are crucial for the host defense mechanism. The selectin family of integral membrane proteins includes E-selectin, L-selectin and P-selectin. Selectins mediate tethering and rolling of leukocytes to the vessel wall at the site of inflammation. The counter-receptor for P-selectin and possibly the other selectins is P-selectin glycoprotein ligand-1 (PSGL-1). This review focuses on the properties and biology of PSGL-1.
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