[HTML][HTML] Glycoprotein Ib–IX-mediated activation of integrin αIIbβ3: effects of receptor clustering and von Willebrand factor adhesion
M Arya, JA Lopez, GM Romo, MA Cruz… - Journal of thrombosis …, 2003 - Elsevier
The interaction between the platelet glycoprotein (GP) Ib–IX complex and von Willebrand
factor (VWF) initiates both hemostasis and pathological thrombosis. This interaction is not
only the first adhesive event of platelets at sites of vessel injury, but also facilitates fibrinogen
binding to α IIb β 3, which subsequently results in platelet aggregation. Since it has been
suggested that GP Ib–IX clustering may promote platelet activation, we investigated the
effect of such clustering on both VWF–GP Ib–IX and fibrinogen–α IIb β 3 bonds using optical …
factor (VWF) initiates both hemostasis and pathological thrombosis. This interaction is not
only the first adhesive event of platelets at sites of vessel injury, but also facilitates fibrinogen
binding to α IIb β 3, which subsequently results in platelet aggregation. Since it has been
suggested that GP Ib–IX clustering may promote platelet activation, we investigated the
effect of such clustering on both VWF–GP Ib–IX and fibrinogen–α IIb β 3 bonds using optical …
