[HTML][HTML] Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides
V Martel, C Racaud-Sultan, S Dupe, C Marie… - Journal of Biological …, 2001 - ASBMB
Talin is a structural component of focal adhesion sites and is thought to be engaged in
multiple protein interactions at the cytoplasmic face of cell/matrix contacts. Talin is a major
link between integrin and the actin cytoskeleton and was shown to play an important role in
focal adhesion assembly. Consistent with the view that talin must be activated at these sites,
we found that phosphatidylinositol 4-monophosphate and phosphatidylinositol 4, 5-
bisphosphate (PI4, 5P 2) bound to talin in cells in suspension or at early stages of adhesion …
multiple protein interactions at the cytoplasmic face of cell/matrix contacts. Talin is a major
link between integrin and the actin cytoskeleton and was shown to play an important role in
focal adhesion assembly. Consistent with the view that talin must be activated at these sites,
we found that phosphatidylinositol 4-monophosphate and phosphatidylinositol 4, 5-
bisphosphate (PI4, 5P 2) bound to talin in cells in suspension or at early stages of adhesion …