[HTML][HTML] Identification of a talin-binding site in the integrin β3 subunit distinct from the NPLY regulatory motif of post-ligand binding functions: the talin n-terminal head …
S Patil, A Jedsadayanmata, JD Wencel-Drake… - Journal of Biological …, 1999 - ASBMB
Following platelet aggregation, integrin α IIb β 3 becomes associated with the platelet
cytoskeleton. The conserved NPLY sequence represents a potential β-turn motif in the β 3
cytoplasmic tail and has been suggested to mediate the interaction of β 3 integrins with talin.
In the present study, we performed a double mutation (N744Q/P745A) in the integrin β 3
subunit to test the functional significance of this β-turn motif. Chinese hamster ovary cells
were co-transfected with cDNA constructs encoding mutant β 3 and wild type α IIb. Cells …
cytoskeleton. The conserved NPLY sequence represents a potential β-turn motif in the β 3
cytoplasmic tail and has been suggested to mediate the interaction of β 3 integrins with talin.
In the present study, we performed a double mutation (N744Q/P745A) in the integrin β 3
subunit to test the functional significance of this β-turn motif. Chinese hamster ovary cells
were co-transfected with cDNA constructs encoding mutant β 3 and wild type α IIb. Cells …